{"application":{"applicationId":1462,"applicationNumber":0,"applicationType":null,"applicationStatusCode":null,"publish":false,"noohDate":null,"mode":null,"pioneerApplicationNumber":0},"applicationSponsor":null,"applicationProprietary":null,"applicationIngredients":null,"applicationExclusivity":{"application":null,"exclusivityBean":[]},"applicationPatent":{"application":null,"patentBean":[]},"documents":{"eaFonsiBean":[],"foi":[{"foiId":420,"applicationId":1462,"approvalTypeId":1,"approvalType":"Original","approvalDate":"03/02/1987","summary":"For use in dogs to prevent canine heartworm disease. HEARTGARD-30 (ivermectin) eliminates the tissue stage of heartworm larvae (\n<i>Dirofilaria immitis</i> ).","fileName":"UCM472677.pdf","file":null,"fileContent":null,"createDate":null,"createOperator":null,"updateDate":null,"updateOperator":null}],"blueBirdLabel":[],"labeling":[],"eaFonsi":[]},"proprietaryPreviewBean":[{"proprietaryNameId":1953,"applicationId":null,"statusDescription":"RX","doseFormName":"Tablet","proprietaryName":"Heartgard 30®","specifications":"Each tablet or cube contains 68 micrograms of ivermectin.","sortOrder":0,"routes":["Oral"],"withdrawals":[],"species":{"Dogs:29":"Dog, Excluding Under 6 Weeks Age"},"ailHeader":[{"ailHeader":"Dogs","ails":[{"dosageAmount":"6.0 micrograms per kilogram body weight (2.72 micrograms per pound), minimum. \r\nup to 25 pounds, 68 micrograms; \r\n26 to 50 pounds 136 micrograms; \r\n51 to 100 pounds, 272 micrograms;   \r\nover 100 pounds, a combination of the appropriate tablets. \r\nThe drug is administered at monthly dosing intervals.","indication":"To prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (<i>Dirofilaria immitis</i>) for 1 month (30 days) after infection.","limitation":"Use once-a-month.  Recommended for dogs 6 weeks of age and older.  Initial use within 1 month after first exposure to mosquitoes.  Final use within 1 month after last exposure to mosquitoes.  Federal law restricts this drug to use by or on the order of a licensed veterinarian."}]}]},{"proprietaryNameId":1954,"applicationId":null,"statusDescription":"RX","doseFormName":"Tablet","proprietaryName":"Heartgard® Tablets","specifications":"Each tablet or cube contains 68 micrograms of ivermectin.","sortOrder":0,"routes":["Oral"],"withdrawals":[],"species":{"Dogs:29":"Dog, Excluding Under 6 Weeks Age"},"ailHeader":[{"ailHeader":"Dogs","ails":[{"dosageAmount":"6.0 micrograms per kilogram body weight (2.72 micrograms per pound), minimum. \r\nup to 25 pounds, 68 micrograms; \r\n26 to 50 pounds 136 micrograms; \r\n51 to 100 pounds, 272 micrograms;   \r\nover 100 pounds, a combination of the appropriate tablets. \r\nThe drug is administered at monthly dosing intervals.","indication":"To prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (<i>Dirofilaria immitis</i>) for 1 month (30 days) after infection.","limitation":"Use once-a-month.  Recommended for dogs 6 weeks of age and older.  Initial use within 1 month after first exposure to mosquitoes.  Final use within 1 month after last exposure to mosquitoes.  Federal law restricts this drug to use by or on the order of a licensed veterinarian."}]}]}],"ingredientsPreviewBean":[{"activeIngredientName":"Ivermectin","activeIngredientTolerance":"<p>A tolerance is established for 22,23-dihydroavermectin B1a (marker residue) in liver (target tissue) as follows: a. In cattle 1.6 parts per million. b. In swine 20 parts per billion. c. In sheep 30 parts per billion. d. In reindeer 15 parts per billion. e. In American bison 15 parts per billion. Muscle residues are not indicative of the safety of other edible tissues. A tolerance is established for 22,23-dihydroavermectin B1a (marker residue) in muscle as follows: a. Swine 20 parts per billion b. Cattle 0.65 parts per million</p>"}],"sponsorPreviewBean":{"sponsorName":"Boehringer lngelheim Animal Health USA, Inc.","address1":"4000 Medley Blvd.","address2":"Suite 300","city":"Johns Creek","state":"Georgia","postalCode":"30097","stateCode":"GA","countryName":"United States"}}